Endocrine Abstracts

Introduction: Non-classical congenital adrenal hyperplasia (NCCAH) is considered to be a common monogenic inherited disease, with an incidence range from 1:500 to 1:100 births worldwide. NCCAH is often peri or post pubertal pauci or even asymptomatic. We report the case of a young girl with severe hirsutism and sexual ambiguity, despite late disclosure.Observation: This is the case of a 16-year-old girl, with a history of menarche at the age of 14, prese...

Introduction: TSH-secreting pituitary neuroendocrine tumor (TSH-PitNET) is the rarest pituitary tumors. Most TSH-PitNETs are secreting, with a biological profile of inappropriate TSH secretion (moderately elevated TSH, elevated FT3 and FT4).Observation: We report the case of a 69-year-old patient, with a history of total thyroidectomy in 2014 for multinodular goiter, hospitalized for suspected levothyroxine pseudo-malabsorption. Despite doses above 2 &#1...

Te paraneoplastic Cushing’s syndrome represents 9 to 18% of ACTH-dependent endogenous hypercorticisms; which poses, in clinical practice, two types of problems:– on the one hand, the differential diagnosis with Cushing’s disease, when well differentiated and morphologically undetectable endocrine tumors are involved.– on the other hand, the control of hypercortism, most often major in metastatic neuroendocri...

Introduction: Mitotane is an adrenolytic drug that is used as an adjuvant to treat adrenocortical carcinoma, The side effects of lysodren are numerous, but some of them are less known. We report a case of ovarian cyst in a woman of childbearing age. It is a 26 years old patient treated with Lysodren® for a locoregional recurrence of an adrenal cacinoma stage II of the ENSAT. After 9 months of treatment, the patient presented an amenorrhea, with the appearance of a large o...

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. The aim of this presentation is to report tow cases of a virilizing androgen-secreting adrenal oncocytoma.Case description: Case 1: A 27-year-old female was admitted to our clinic with a 116 mm left adrenal incidentaloma. The patient’s main symptom was hirsutism. Upon investigation, elevated values of testosterone, and DHEA-S were foun...

Central diabetes insipidus (CDI) is rare in children and has a wide variety of causes. In children, the majority of central DI is acquired, but 30 to 50% is considered idiopathic. However, the natural history of isolated idiopathic central ID is unpredictable and germinoma should always be considered during the first 3 years of follow-up.Case report: We report the observation of a 16 year old patient, in whom the diagnosis of idiopathic central diabetes ...

Introduction: Adrenal oncocytomas are rare and usually present as incidentally detected masses. The aim of this study is to evaluate the clinical characteristics of a series of patients with adrenal oncocytoma.Material and Methods: we retrospectively collated all patients admitted to Bologhine Hospital between 2010 and 2020 for adrenal masses and who underwent surgery and a diagnosis of adrenal oncocytoma at the anathomo-pathological study (n=07...

Introduction: The diagnosis of primary hyperaldosteronism (PAH) is based on the realization of the renin aldosterone ratio (RAR). The presence of renal insufficiency (RI) in a hypertensive patient complicates this diagnosis by affecting various biological assays.Observation: We report the case of 25-year-old female, with a personal history of primary hypothyroidism, hypertension diagnosed at age 21 and severe renal insufficiency developed during a pregna...

Introduction: Spindle cell oncocytoma (SCO) of the pituitary gland is a rare thyroid transcription factor 1 (TTF-1)-positive pituitary neoplasm.Observation: We report the case of a 42-year-old man, with a personal history of type 2 diabetes, consulting for intense headaches and vomiting. The visual field shows an amputation of the left temporal hemifield and the MRI shows a pituitary adenoma with suprasellar development, initially measuring 22×28&#2...

Introduction: Thyroid tuberculosis is a rare entity even in countries like Algeria where tuberculosis is endemic.Observation: We report the case of a 40-year-old woman, with a history of hypertension and severe renal failure, consulting for recent cervical swelling evolving in a context of asthenia, nocturnal fever and weight loss. The clinical examination found a compressive goitre. The biological assessment objectified a primary hypothyroidism and an i...